Gundry writes, “The phrase ‘in Ephesus,’ which refers to the locale of the addresses (1:1), is missing in the most ancient manuscripts. Thus, Paul omits the geographical location of the addresses altogether.” Robert Gundry, A Survey of the New Testament (Grand Rapids, MI: Zondervan, 2003), 422.
John Stott writes, “The words ‘at Ephesus’ are not to be found, however, in the earliest Pauline papyrus (Chester Beatty 46) which dates from the second century. Origen in the third century did not know them, and they are absent from the great fourth-century Vatican and Sinaitic codices. The matter is further complicated by the fact that Marcion in the middle of the second century referred to Ephesians as having been addressed ‘to the Laodiceans’. Since Paul himself directed the Colossians both to see that his letter to them be read ‘in the church of the Laodiceans’ and that they themselves ‘read also the letter from Laodicea’, some have thought that this so-called ‘letter from Laodicea’ was in fact our ‘Ephesians’, and that he was instructing the churches to exchange the two letters which they had received from him. Certainly Tychicus was the bearer of the two letters.” John Stott, God’s New Society: The Message of Ephesians (Downers Grove, Ill.: InterVarsity Press, 1979), 23-24.